AMPA

AMPA
	IUPAC名; 2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid
识别
CAS号	74341-63-2
PubChem	1221
ChemSpider	1184
SMILES	O=C1/C(=C(\ON1)C)CC(N)C(=O)O;
InChI	1/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12);
InChIKey	UUDAMDVQRQNNHZ-UHFFFAOYAT
DrugBank	DB02057
MeSH	AMPA
IUPHAR配体	4131
性质
化学式	C7H10N2O4
摩尔质量	186.17 g·mol−1
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

AMPA（α-氨基-3-羟基-5-甲基-4-异恶唑丙酸），是一种化合物，AMPA受体的特异性激动剂，能模仿神经递质谷氨酸的作用。^[1]

中枢神经系统中有几种谷氨酸能离子通道，包括AMPA、红藻氨酸和N-甲基-D-天冬氨酸（NMDA）通道。在突触中，这些受体的用途非常不同。AMPA可在实验中区分受体间活性的差异，以了解它们的功能。^[2]AMPA可产生快速兴奋性突触后电位（EPSP）。^[1]AMPA能激活作AMPA受体（一种非选择性阳离子通道），允许Na⁺和K⁺通过，逆转电位接近0毫伏。

克罗格斯加德·拉森、奥诺雷等人合成了AMPA以及其他数种鹅膏蕈氨酸衍生物，以区分谷氨酸敏感受体和天冬氨酸敏感受体。^[3]

参见

安帕金

参考文献

^ ^1.0 ^1.1 Purves, Dale; George J. Augustine; David Fitzpatrick; William C. Hall; Anthony-Samuel LaMantia; James O. McNamara; Leonard E. White. Neuroscience 4th. Sinauer Associates. 2008: 128–33. ISBN 978-0-87893-697-7. Purves, Dale; George J. Augustine; David Fitzpatrick; William C. Hall; Anthony-Samuel LaMantia; James O. McNamara & Leonard E. White (2008). Neuroscience (4th ed.). Sinauer Associates. pp. 128–33. ISBN 978-0-87893-697-7.
^ Dinh, L; Nguyen T; Salgado H; Atzori M. Norepinephrine homogeneously inhibits alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate- (AMPAR-) mediated currents in all layers of the temporal cortex of the rat. Neurochem Res. 2009, 34 (11): 1896–906. PMID 19357950. doi:10.1007/s11064-009-9966-z.
^ Krogsgaard-Larsen, P; Honore T; Hansen JJ; Curtis DR; Lodge D. New class of glutamate agonist structurally related to ibotenic acid. Nature. 1980, 284: 64–66. PMID 6101908. doi:10.1038/284064a0.

[Purves2008-1] 1.0 ^1.1 Purves, Dale; George J. Augustine; David Fitzpatrick; William C. Hall; Anthony-Samuel LaMantia; James O. McNamara; Leonard E. White. Neuroscience 4th. Sinauer Associates. 2008: 128–33. ISBN 978-0-87893-697-7. Purves, Dale; George J. Augustine; David Fitzpatrick; William C. Hall; Anthony-Samuel LaMantia; James O. McNamara & Leonard E. White (2008). Neuroscience (4th ed.). Sinauer Associates. pp. 128–33. ISBN 978-0-87893-697-7.

[Dinh2009-2] Dinh, L; Nguyen T; Salgado H; Atzori M. Norepinephrine homogeneously inhibits alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate- (AMPAR-) mediated currents in all layers of the temporal cortex of the rat. Neurochem Res. 2009, 34 (11): 1896–906. PMID 19357950. doi:10.1007/s11064-009-9966-z.

[KrogsgaardLarsen1980-3] Krogsgaard-Larsen, P; Honore T; Hansen JJ; Curtis DR; Lodge D. New class of glutamate agonist structurally related to ibotenic acid. Nature. 1980, 284: 64–66. PMID 6101908. doi:10.1038/284064a0.

[1]

[2]

[3]