AMPA

AMPA
	IUPAC名; 2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid
識別
CAS號	74341-63-2
PubChem	1221
ChemSpider	1184
SMILES	O=C1/C(=C(\ON1)C)CC(N)C(=O)O;
InChI	1/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12);
InChIKey	UUDAMDVQRQNNHZ-UHFFFAOYAT
DrugBank	DB02057
MeSH	AMPA
IUPHAR配體	4131
性質
化學式	C7H10N2O4
摩爾質量	186.17 g·mol−1
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

AMPA（α-氨基-3-羥基-5-甲基-4-異惡唑丙酸），是一種化合物，AMPA受體的特異性激動劑，能模仿神經遞質穀氨酸的作用。^[1]

中樞神經系統中有幾種穀氨酸能離子通道，包括AMPA、紅藻氨酸和N-甲基-D-天冬氨酸（NMDA）通道。在突觸中，這些受體的用途非常不同。AMPA可在實驗中區分受體間活性的差異，以了解它們的功能。^[2]AMPA可產生快速興奮性突觸後電位（EPSP）。^[1]AMPA能激活作AMPA受體（一種非選擇性陽離子通道），允許Na⁺和K⁺通過，逆轉電位接近0毫伏。

克羅格斯加德·拉森、奧諾雷等人合成了AMPA以及其他數種鵝膏蕈氨酸衍生物，以區分穀氨酸敏感受體和天冬氨酸敏感受體。^[3]

參見

安帕金

參考文獻

^ ^1.0 ^1.1 Purves, Dale; George J. Augustine; David Fitzpatrick; William C. Hall; Anthony-Samuel LaMantia; James O. McNamara; Leonard E. White. Neuroscience 4th. Sinauer Associates. 2008: 128–33. ISBN 978-0-87893-697-7. Purves, Dale; George J. Augustine; David Fitzpatrick; William C. Hall; Anthony-Samuel LaMantia; James O. McNamara & Leonard E. White (2008). Neuroscience (4th ed.). Sinauer Associates. pp. 128–33. ISBN 978-0-87893-697-7.
^ Dinh, L; Nguyen T; Salgado H; Atzori M. Norepinephrine homogeneously inhibits alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate- (AMPAR-) mediated currents in all layers of the temporal cortex of the rat. Neurochem Res. 2009, 34 (11): 1896–906. PMID 19357950. doi:10.1007/s11064-009-9966-z.
^ Krogsgaard-Larsen, P; Honore T; Hansen JJ; Curtis DR; Lodge D. New class of glutamate agonist structurally related to ibotenic acid. Nature. 1980, 284: 64–66. PMID 6101908. doi:10.1038/284064a0.

[Purves2008-1] 1.0 ^1.1 Purves, Dale; George J. Augustine; David Fitzpatrick; William C. Hall; Anthony-Samuel LaMantia; James O. McNamara; Leonard E. White. Neuroscience 4th. Sinauer Associates. 2008: 128–33. ISBN 978-0-87893-697-7. Purves, Dale; George J. Augustine; David Fitzpatrick; William C. Hall; Anthony-Samuel LaMantia; James O. McNamara & Leonard E. White (2008). Neuroscience (4th ed.). Sinauer Associates. pp. 128–33. ISBN 978-0-87893-697-7.

[Dinh2009-2] Dinh, L; Nguyen T; Salgado H; Atzori M. Norepinephrine homogeneously inhibits alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate- (AMPAR-) mediated currents in all layers of the temporal cortex of the rat. Neurochem Res. 2009, 34 (11): 1896–906. PMID 19357950. doi:10.1007/s11064-009-9966-z.

[KrogsgaardLarsen1980-3] Krogsgaard-Larsen, P; Honore T; Hansen JJ; Curtis DR; Lodge D. New class of glutamate agonist structurally related to ibotenic acid. Nature. 1980, 284: 64–66. PMID 6101908. doi:10.1038/284064a0.

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