老化防护

老化防护指的是一类以老化和老化相关疾病的肇因为目标、因而可能延长动物寿命的老化防护疗法。^[1]^[2]^[3]一些可能的老化防护药物包括了褪黑激素^[4]、肌肽^[5]、二甲双胍^[6]、烟酰胺单核苷酸（nicotinamide mononucleotide，缩写为NMN）^[7]^[8]和δ睡眠肽（delta sleep-inducing peptide）^[9]等等。

参照

^ De-novo geroprotector design （页面存档备份，存于互联网档案馆）, SENS Foundation
^ Alexey Moskalev, Elizaveta Chernyagina, Anna Kudryavtseva & Mikhail Shaposhnikov. Geroprotectors: A Unified Concept and Screening Approaches. Aging and Disease. 2017, 8 (3): 354–363. PMC 5440114 . PMID 28580190. doi:10.14336/AD.2016.1022.
^ Alexey Moskalev, Elizaveta Chernyagina, Joao Pedro de Magalhaes & Alex Zhavoronkov. Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease. Aging. 2015, 7 (9): 616–628. PMC 4600621 . PMID 26342919. doi:10.18632/aging.100799.
^ Anisimov, VN; Popovich, IG; Zabezhinski, MA; Anisimov, SV; Vesnushkin, GM; Vinogradova, IA. Melatonin as antioxidant, geroprotector and anticarcinogen. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 2006, 1757 (5–6): 573–89. PMID 16678784. doi:10.1016/j.bbabio.2006.03.012.
^ Boldyrev, AA; Stvolinsky, SL; Fedorova, TN; Suslina, ZA. Carnosine as a natural antioxidant and geroprotector: From molecular mechanisms to clinical trials. Rejuvenation Research. 2010, 13 (2–3): 156–8. PMID 20017611. doi:10.1089/rej.2009.0923.
^ Bulterijs, S. Metformin As a Geroprotector. Rejuvenation Research. 2011, 14 (5): 469–82. PMID 21882902. S2CID 40645408. doi:10.1089/rej.2011.1153.
^ Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice （页面存档备份，存于互联网档案馆）, Cell Metabolism 24, 795–806, December 13, 2016 ª 2016 Elsevier Inc.
^ 長壽藥”NMN腫瘤能不能喫？不得不說的NMN副作用大全. 互动头条. [2020-11-30]. （原始内容存档于2020-12-11）（中文（台湾））.
^ Bondarenko, TI. Mechanism of delta-sleep inducing peptide geroprotective activity. Adv Gerontol. 2011, 24 (1): 80–92. PMID 21809625.

参见

返老药

外部链接

Geroprotectors （页面存档备份，存于互联网档案馆）─一个关于老化防护药物数据库。
Aging Chart （页面存档备份，存于互联网档案馆）─一个由社群管理的和老化相关的生化路径与知识的集合。

这是一篇与医学相关的小作品。您可以通过编辑或修订扩充其内容。

[1] De-novo geroprotector design （页面存档备份，存于互联网档案馆）, SENS Foundation

[2] Alexey Moskalev, Elizaveta Chernyagina, Anna Kudryavtseva & Mikhail Shaposhnikov. Geroprotectors: A Unified Concept and Screening Approaches. Aging and Disease. 2017, 8 (3): 354–363. PMC 5440114 . PMID 28580190. doi:10.14336/AD.2016.1022.

[3] Alexey Moskalev, Elizaveta Chernyagina, Joao Pedro de Magalhaes & Alex Zhavoronkov. Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease. Aging. 2015, 7 (9): 616–628. PMC 4600621 . PMID 26342919. doi:10.18632/aging.100799.

[4] Anisimov, VN; Popovich, IG; Zabezhinski, MA; Anisimov, SV; Vesnushkin, GM; Vinogradova, IA. Melatonin as antioxidant, geroprotector and anticarcinogen. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 2006, 1757 (5–6): 573–89. PMID 16678784. doi:10.1016/j.bbabio.2006.03.012.

[5] Boldyrev, AA; Stvolinsky, SL; Fedorova, TN; Suslina, ZA. Carnosine as a natural antioxidant and geroprotector: From molecular mechanisms to clinical trials. Rejuvenation Research. 2010, 13 (2–3): 156–8. PMID 20017611. doi:10.1089/rej.2009.0923.

[6] Bulterijs, S. Metformin As a Geroprotector. Rejuvenation Research. 2011, 14 (5): 469–82. PMID 21882902. S2CID 40645408. doi:10.1089/rej.2011.1153.

[7] Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice （页面存档备份，存于互联网档案馆）, Cell Metabolism 24, 795–806, December 13, 2016 ª 2016 Elsevier Inc.

[8] 長壽藥”NMN腫瘤能不能喫？不得不說的NMN副作用大全. 互动头条. [2020-11-30]. （原始内容存档于2020-12-11）（中文（台湾））.

[9] Bondarenko, TI. Mechanism of delta-sleep inducing peptide geroprotective activity. Adv Gerontol. 2011, 24 (1): 80–92. PMID 21809625.

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