ABT-670

ABT-670
识别信息
	IUPAC命名法 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide; ;
CAS号	630119-43-6
PubChem CID	16094676;
ChemSpider	17252978 ;
UNII	4L6071XH2J;
ChEMBL	ChEMBL219182 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID30212235 ;
化学信息
化学式	C19H23N3O2
摩尔质量	325.41 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES [O-][n+]1ccccc1C(CC3)CCN3CNC(=O)c(c2)cccc2C;
	InChI InChI=1S/C19H23N3O2/c1-15-5-4-6-17(13-15)19(23)20-14-21-11-8-16(9-12-21)18-7-2-3-10-22(18)24/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,20,23) ; Key:PUMMPCXNEPHBNN-UHFFFAOYSA-N ;

它可以2-(4-哌啶基)吡啶-N-氧化物盐酸盐、3-甲基苯甲酰胺（维基数据所列：Q83085589）和甲醛为原料合成得到。^[1]^[2]

参考文献

^ ^1.0 ^1.1 Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, et al. Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. Journal of Medicinal Chemistry. December 2006, 49 (25): 7450–65. PMID 17149874. doi:10.1021/jm060662k.
^ Bhatia, Pramila A.; Daanen, Jerome F.; Hakeem, Ahmed A.; Kolasa, Teodozyj; Matulenko, Mark A.; Mortell, Kathleen H.; Patel, Meena V.; Stewart, Andrew O.; Wang, Xueqing; Xia, Zhiren; Zhang, Henry Q. Preparation of piperazinyl, piperidinyl and related acetamides and benzamides as dopamine D4 receptor agonists useful in treating sexual dysfunction. 2003. US20030229094 A1.

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