3-羟酰辅酶A脱氢酶

3-羟酰辅酶A脱氢酶
3-羟酰辅酶A脱氢酶的结构（PDB 3had）
命名 系统命名 (S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase 缩写 别名 β-hydroxyacyl dehydrogenase; β-keto-reductase; 3-keto reductase; 3-hydroxyacyl coenzyme A dehydrogenase; β-hydroxyacyl-coenzyme A synthetase; β-hydroxyacylcoenzyme A dehydrogenase; β-hydroxybutyrylcoenzyme A dehydrogenase; 3-hydroxyacetyl-coenzyme A dehydrogenase; L-3-hydroxyacyl coenzyme A dehydrogenase; L-3-hydroxyacyl CoA dehydrogenase; β-hydroxyacyl CoA dehydrogenase; 3β-hydroxyacyl coenzyme A dehydrogenase; 3-hydroxybutyryl-CoA dehydrogenase; β-ketoacyl-CoA reductase; β-hydroxy acid dehydrogenase; 3-L-hydroxyacyl-CoA dehydrogenase; 3-hydroxyisobutyryl-CoA dehydrogenase; 1-specific DPN-linked β-hydroxybutyric dehydrogenase
识别码
EC编号	1.1.1.35
CAS号	9028-40-4
数据库
IntEnz	IntEnz浏览
BRENDA	BRENDA入口
ExPASy	NiceZyme浏览
KEGG	KEGG入口
MetaCyc	代谢路径
PRIAM	概述
PDB	RCSB PDB PDBj PDBe PDBsum
基因本体	AmiGO / EGO
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3-羟酰辅酶A脱氢酶（英语：3-hydroxyacyl-CoA dehydrogenase，EC 1.1.1.35（页面存档备份，存于互联网档案馆））是一种以NAD⁺或NADP⁺为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应：

(S)-3-羟酰辅酶A + NAD⁺ $\rightleftharpoons$ 3-氧酰辅酶A + NADH + H⁺

3-羟酰辅酶A脱氢酶主要参与脂肪酸的代谢过程，如β-氧化的第三步等。

参考文献

• Hillmer P and Gottschalk G. Solubilization and partial characterisation of particulate dehydrogenases from Clostridium kluyveri. Biochim. Biophys. Acta. 1974, 334: 12–23. 
• Lehninger AL, Greville GD. The enzymic oxidation of alpha- and 2-beta-hydroxybutyrate. Biochim. Biophys. Acta. 1953, 12 (1-2): 188–202. PMID 13115428. doi:10.1016/0006-3002(53)90138-3. * Stern JR. Crystalline beta-hydroxybutyryl dehydrogenase from pig heart. Biochim. Biophys. Acta. November 1957, 26 (2): 448–9. PMID 13499396. doi:10.1016/0006-3002(57)90040-9. 
• Wakil SJ, Green DE, Mii S and Mahler HR. Studies on the fatty acid oxidizing system of animal tissues. VI. beta-Hydroxyacyl coenzyme A dehydrogenase. J. Biol. Chem. April 1954, 207 (2): 631–8. PMID 13163047.