尚卡爾·巴拉蘇布拉馬尼安

教授
Shankar Balasubramanian爵士
FRS FMedSci（英語：Fellow of the Academy of Medical Sciences）
教授; Shankar Balasubramanian爵士; FRS FMedSci（英語：Fellow of the Academy of Medical Sciences）
出生	1966年9月30日（58歲）; 印度欽奈
國籍	英國
母校	劍橋大學
知名於	核酸研究; G-quadruplexes; Solexa測序技術;
獎項	Corday-Morgan Prize (2002); EMBO Member (2013); Tetrahedron Prize (2013); 皇家獎章 (2018); 千禧年技術獎 (2020); 生命科學突破獎 (2022); 蓋爾德納國際獎 (2024);
網站	www.ch.cam.ac.uk/group/shankar https://www.cruk.cam.ac.uk/research-groups/balasubramanian-group
	科學生涯
機構	劍橋大學; 賓夕法尼亞州立大學; 英國癌症研究所; Cambridge Epigenetix; Solexa; 劍橋三一學院;
論文	Studies on the reaction mechanism of chorismate synthase（1992）
博士導師	Chris Abell
博士生	Julian Huppert

尚卡爾·巴拉蘇布拉馬尼安，英國化學家^[4]^[5]和劍橋大學化學系Herchel-Smith藥物化學教授^[6]^[7] ，英國癌症研究所高級小組組長和劍橋三一學院研究員。^[8] 他因在核酸領域的貢獻而知名。他是Solexa和biomodal（正式名稱為Cambridge Epigenetix）的科學創始人。^[9]^[10]

早年

尚卡爾1966年出生於印度馬德拉斯（今欽奈），1967年隨父母移居英國。他在柴郡倫科恩郊外的一個村子長大，就讀於Daresbury小學，然後升入Appleton Hall高中（後合併為Bridgewater高中）。1985至1988年，他在劍橋菲茨威廉學院學習理科，獲本科學位，之後在Chris Abell指導下研究分支酸合酶的反應機制，1991年獲博士學位。^[11]^[12]

研究生涯

尚卡爾於1994年在劍橋大學開始了獨立的學術生涯，此後一直擔任學院講師，然後擔任大學講師（1998年）、大學化學生物學講師（2003年）和化學生物學教授（2007年）。他於2008年被任命為Herchel Smith藥物化學教授。^[13]

尚卡爾是核酸領域的權威學者，他主導了下一代測序方法——Solexa測序的發明，該方法為人類基因組的常規、準確、低成本測序奠定基礎。他對非編碼遺傳元件的鑑定、闡明和操縱做出了貢獻，特別是被稱為G-四鏈體的四鏈結構。他利用小分子干預核酸功能的工作揭示了許多分子機制，對癌症研究有重大影響。^[14]

參考資料

^ ^1.0 ^1.1 Anon. https://www.ukwhoswho.com/view/article/oupww/whoswho/U256669 |chapter-url=缺少標題 (幫助). 英国名人录. ukwhoswho.com online Oxford University Press (布盧姆斯伯里出版公司旗下A & C Black). 2017. doi:10.1093/ww/9780199540884.013.256669. 需要訂閱或英國公共圖書館會員資格
^ Huppert, J. L.; Balasubramanian, S. Prevalence of quadruplexes in the human genome. Nucleic Acids Research. 2005, 33 (9): 2908–2916. PMC 1140081 . PMID 15914667. doi:10.1093/nar/gki609.
^ Huppert, Julian Leon. Studies on genomic G-quadruplexes. lib.cam.ac.uk (PhD論文) (University of Cambridge). 2005. OCLC 885437272. EThOS uk.bl.ethos.604822.
^ Balasubramanian, S. From DNA to mountain climbing. Shankar Balasubramanian talks to Alison Stoddart about his research and other interests. Molecular BioSystems. 2007, 3 (5): B37. PMID 17582897.
^ Balasubramanian, S. An interview with Shankar Balasubramanian. Trends in Biochemical Sciences. 2013, 38 (4): 170–1. PMID 23522090. doi:10.1016/j.tibs.2013.02.006.
^ University of Cambridge, 2013. The Balasubramanian Group.. [Accessed 4 April 2013].
^ Professor Sir Shankar Balasubramanian FMedSci FRS. Yusuf Hamied Department of Chemistry. [13 December 2021].
^ Master & Fellows. Trinity College Cambridge. 10 November 2021 [13 December 2021].
^ Shankar Balasubramanian. biomodal integrates multiple modes of biology from a single sample in a single experiment to provide transformative insights into health and disease. 19 January 2020 [13 December 2021].
^ Shankar BALASUBRAMANIAN. companieshouse.gov.uk. London: Companies House. （原始內容存檔於2016-07-06）.
^ Balasubramanian, Shankar. Studies on the reaction mechanism of chorismate synthase. lib.cam.ac.uk (PhD論文) (University of Cambridge). 1991. OCLC 60112382. EThOS uk.bl.ethos.386780.
^ Fitz alumni on top science list. Fitzwilliam College. 2014 [6 February 2014]. （原始內容存檔於22 February 2014）.
^ Home. Balasubramanian Group. 19 August 2016 [13 December 2021].
^ Shankar Balasubramanian | Royal Society.

[whoswho-1] 1.0 ^1.1 Anon. https://www.ukwhoswho.com/view/article/oupww/whoswho/U256669 |chapter-url=缺少標題 (幫助). 英国名人录. ukwhoswho.com online Oxford University Press (布盧姆斯伯里出版公司旗下A & C Black). 2017. doi:10.1093/ww/9780199540884.013.256669. 需要訂閱或英國公共圖書館會員資格

[Huppert2005-2] Huppert, J. L.; Balasubramanian, S. Prevalence of quadruplexes in the human genome. Nucleic Acids Research. 2005, 33 (9): 2908–2916. PMC 1140081 . PMID 15914667. doi:10.1093/nar/gki609.

[huphd-3] Huppert, Julian Leon. Studies on genomic G-quadruplexes. lib.cam.ac.uk (PhD論文) (University of Cambridge). 2005. OCLC 885437272. EThOS uk.bl.ethos.604822.

[4] Balasubramanian, S. From DNA to mountain climbing. Shankar Balasubramanian talks to Alison Stoddart about his research and other interests. Molecular BioSystems. 2007, 3 (5): B37. PMID 17582897.

[5] Balasubramanian, S. An interview with Shankar Balasubramanian. Trends in Biochemical Sciences. 2013, 38 (4): 170–1. PMID 23522090. doi:10.1016/j.tibs.2013.02.006.

[www-shankar.ch.cam.ac.uk-6] University of Cambridge, 2013. The Balasubramanian Group.. [Accessed 4 April 2013].

[Yusuf_Hamied_Department_of_Chemistry-7] Professor Sir Shankar Balasubramanian FMedSci FRS. Yusuf Hamied Department of Chemistry. [13 December 2021].

[Trinity_College_Cambridge_2021_3-8] Master & Fellows. Trinity College Cambridge. 10 November 2021 [13 December 2021].

[Cambridge_Epigenetix_has_a_vision_to_improve_healthcare_through_routine_measurement_of_the_epigenome._2020-9] Shankar Balasubramanian. biomodal integrates multiple modes of biology from a single sample in a single experiment to provide transformative insights into health and disease. 19 January 2020 [13 December 2021].

[gov-10] Shankar BALASUBRAMANIAN. companieshouse.gov.uk. London: Companies House. （原始內容存檔於2016-07-06）.

[shankarphd-11] Balasubramanian, Shankar. Studies on the reaction mechanism of chorismate synthase. lib.cam.ac.uk (PhD論文) (University of Cambridge). 1991. OCLC 60112382. EThOS uk.bl.ethos.386780.

[fitz-12] Fitz alumni on top science list. Fitzwilliam College. 2014 [6 February 2014]. （原始內容存檔於22 February 2014）.

[Balasubramanian_Group_2016-13] Home. Balasubramanian Group. 19 August 2016 [13 December 2021].

[14] Shankar Balasubramanian | Royal Society.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]