疊氮乙酸乙酯
外觀
疊氮乙酸乙酯 | |
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識別 | |
CAS號 | 637-81-0 |
PubChem | 69480 |
SMILES |
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InChI |
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InChIKey | HVJJYOAPXBPQQV-UHFFFAOYSA-N |
性質 | |
化學式 | C4H7N3O2 |
摩爾質量 | 129.12 g·mol−1 |
密度 | 1.1181 g·cm-3(25 °C)[1] |
沸點 | 74—75 °C(347—348 K)(23 mmHg)[1] 164 °C(437 K)(760 mmHg)[2] |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
疊氮乙酸乙酯是一種有機化合物,化學式為C4H7N3O2。它可以溴乙酸乙酯和疊氮化鈉為原料反應製得。[1]它和苯乙炔在催化下反應,可以得到4-苯基-1H-1,2,3-三唑-1-乙酸乙酯;[3]它和乙酰腈加壓反應,可以得到5-乙酰基-1H-四唑-1-乙酸乙酯。[4]它在50%甲醇水溶液中用氫氧化鋰水解,再酸化後可以得到疊氮乙酸。[5]
參考文獻
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- ^ Zavarzin, I. V.; Zhulin, V. M.; Yarovenko, V. N.; Krayushkin, M. M. Synthesis of 5-acyltetrazoles under high pressure(俄文). Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya,1988. (5): 1168-1170
- ^ Valverde, Ibai E.; Bauman, Andreas; Kluba, Christiane A.; Vomstein, Sandra; Walter, Martin A.; Mindt, Thomas L. 1,2,3‐Triazoles as Amide Bond Mimics: Triazole Scan Yields Protease‐Resistant Peptidomimetics for Tumor Targeting. Angewandte Chemie International Edition (Wiley). 2013-07-05, 52 (34): 8957–8960. ISSN 1433-7851. doi:10.1002/anie.201303108.