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LY-272,015

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LY-272,015
臨床資料
其他名稱LY-272,015; 1-[(3,4-Dimethoxyphenyl)methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole
識別資訊
  • 1-(3,4-dimethoxybenzyl)-6-methyl-2,3,4,9-tetrahydro-1H-β-carboline
CAS號172895-15-7  checkY
PubChem CID
ChemSpider
UNII
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
化學資訊
化學式C21H24N2O2
摩爾質量336.44 g·mol−1
3D模型(JSmol英語JSmol
  • c4cc(C)cc3c4[nH]c2c3CCNC2Cc(cc1OC)ccc1OC
  • InChI=1S/C21H24N2O2/c1-13-4-6-17-16(10-13)15-8-9-22-18(21(15)23-17)11-14-5-7-19(24-2)20(12-14)25-3/h4-7,10,12,18,22-23H,8-9,11H2,1-3H3
  • Key:GDAJGLDMCDMPIR-UHFFFAOYSA-N

LY-272,015是一種有機化合物,化學式為C21H24N2O2,屬於β-咔啉衍生物,能作為血清素受體5-HT2B拮抗劑,由禮來公司作為高血壓藥物研發[1][2]

參考文獻

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  1. ^ Watts SW, Fink GD. 5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCA-salt-hypertensive rats. The American Journal of Physiology. March 1999, 276 (3): H944–52. PMID 10070078. S2CID 13301249. doi:10.1152/ajpheart.1999.276.3.H944. 
  2. ^ Russell A, Banes A, Berlin H, Fink GD, Watts SW. 5-Hydroxytryptamine(2B) receptor function is enhanced in the N(omega)-nitro-L-arginine hypertensive rat. The Journal of Pharmacology and Experimental Therapeutics. October 2002, 303 (1): 179–87. PMID 12235249. S2CID 98055109. doi:10.1124/jpet.102.037390. 

外部連結

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