ADCY7

ADCY7
识别号
别名	ADCY7；, AC7, adenylate cyclase 7
外部ID	OMIM：600385 MGI：102891 HomoloGene：866 GeneCards：ADCY7
基因位置（人类）
染色体	16号染色体
终止	50,318,135 bp
基因位置（小鼠）
染色体	小鼠8号染色体
终止	89,056,590 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• adenylate cyclase activity; • ATP结合; • phosphorus-oxygen lyase activity; • 金属离子结合; • 核苷酸结合; • lyase activity; • guanylate cyclase activity;
细胞组分	• integral component of membrane; • 膜; • 细胞膜; • guanylate cyclase complex, soluble; • 胞内; • integral component of plasma membrane;
生物学过程	• renal water homeostasis; • intracellular signal transduction; • cellular response to ethanol; • cellular response to glucagon stimulus; • cyclic nucleotide biosynthetic process; • maternal process involved in female pregnancy; • cGMP biosynthetic process; • 信号转导; • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; • G protein-coupled receptor signaling pathway; • cAMP biosynthetic process; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • regulation of adaptive immune response; • cellular response to lithium ion; • negative regulation of cytokine production involved in inflammatory response; • activation of adenylate cyclase activity; • activation of protein kinase A activity;
	Sources:Amigo / QuickGO
直系同源
	113
	11513
	ENSG00000121281
	ENSMUSG00000031659
	P51828
	P51829
	NM_001114; NM_001286057
	NM_001037723; NM_001037724; NM_001109756; NM_007406
	NP_001105; NP_001272986
	NP_001032812; NP_001032813; NP_001103226; NP_031432
	维基数据
查看/编辑人类	查看/编辑小鼠

腺苷酰环化酶7（英语：Adenylyl cyclase type 7）是人类ADCY7基因编码的一个酶。^[5]^[6]

功能

这个基因编码与膜结合催化从三磷酸腺苷形成环腺苷酸的腺苷酰环化酶，此过程被钙质抑制。这个基因的产物是腺苷酰环化酶4类/鸟苷酰环化酶家族的一个成员，特点是有个12跨膜结构域。

参考

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000121281 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000031659 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hellevuo K, Berry R, Sikela JM, Tabakoff B. Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16. Hum Genet. Mar 1995, 95 (2): 197–200. PMID 7860067. S2CID 35555146. doi:10.1007/bf00209401.
^ Entrez Gene: ADCY7 adenylate cyclase 7.

延申阅读

Nomura N, Miyajima N, Sazuka T, et al. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. DNA Res. 1995, 1 (1): 27–35. PMID 7584026. doi:10.1093/dnares/1.1.27 .
Nomura N, Miyajima N, Sazuka T, et al. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). DNA Res. 1995, 1 (1): 47–56. PMID 7584028. doi:10.1093/dnares/1.1.47 .
Hellevuo K, Welborn R, Menninger JA, Tabakoff B. Human adenylyl cyclase type 7 contains polymorphic repeats in the 3' untranslated region: investigations of association with alcoholism. Am. J. Med. Genet. 1997, 74 (1): 95–8. PMID 9034014. doi:10.1002/(SICI)1096-8628(19970221)74:1<95::AID-AJMG19>3.0.CO;2-M.
Barcova M, Speth C, Kacani L, et al. Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1. Pflügers Arch. 1999, 437 (4): 538–46. PMID 10089566. S2CID 7620262. doi:10.1007/s004240050815.
Speth C, Joebstl B, Barcova M, Dierich MP. HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. AIDS. 2000, 14 (6): 629–36. PMID 10807185. S2CID 22105709. doi:10.1097/00002030-200004140-00001.
Patke CL, Shearer WT. gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression. J. Allergy Clin. Immunol. 2000, 105 (5): 975–82. PMID 10808179. doi:10.1067/mai.2000.105315.
Patrizio M, Colucci M, Levi G. Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. J. Neurochem. 2001, 77 (2): 399–407. PMID 11299302. S2CID 24053412. doi:10.1046/j.1471-4159.2001.00249.x .
Yan SZ, Tang WJ. Construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase. G Protein Pathways - Part C, Effector Mechanisms. Methods in Enzymology 345. 2002: 231–41. ISBN 978-0-12-182246-0. PMID 11665607. doi:10.1016/S0076-6879(02)45019-7. |journal=被忽略 (帮助)
Speth C, Schabetsberger T, Mohsenipour I, et al. Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons. J. Virol. 2002, 76 (7): 3179–88. PMC 136041 . PMID 11884542. doi:10.1128/JVI.76.7.3179-3188.2002.
Nelson EJ, Hellevuo K, Yoshimura M, Tabakoff B. Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta. J. Biol. Chem. 2003, 278 (7): 4552–60. PMID 12454008. doi:10.1074/jbc.M210386200 .
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ludwig MG, Seuwen K. Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. J. Recept. Signal Transduct. Res. 2003, 22 (1–4): 79–110. PMID 12503609. S2CID 36697419. doi:10.1081/RRS-120014589.
Ota T, Suzuki Y, Nishikawa T, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285 .
Gerhard DS, Wagner L, Feingold EA, et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Beeler JA, Yan SZ, Bykov S, et al. A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase. Biochemistry. 2005, 43 (49): 15463–71. CiteSeerX 10.1.1.558.7519 . PMID 15581358. doi:10.1021/bi049088+.
Kimura K, Wakamatsu A, Suzuki Y, et al. Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes. Genome Res. 2006, 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
Hines LM, Hoffman PL, Bhave S, et al. A sex-specific role of type VII adenylyl cyclase in depression. J. Neurosci. 2006, 26 (48): 12609–19. PMC 6674903 . PMID 17135423. doi:10.1523/JNEUROSCI.1040-06.2006 .

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000121281 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000031659 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7860067-5] Hellevuo K, Berry R, Sikela JM, Tabakoff B. Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16. Hum Genet. Mar 1995, 95 (2): 197–200. PMID 7860067. S2CID 35555146. doi:10.1007/bf00209401.

[entrez-6] Entrez Gene: ADCY7 adenylate cyclase 7.

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