特他洛尔
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| 臨床資料 | |
|---|---|
| AHFS/Drugs.com | 国际药品名称 |
| 给药途径 | 口服 |
| ATC碼 | |
| 法律規範狀態 | |
| 法律規範 |
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| 识别信息 | |
| |
| CAS号 | 83688-84-0  |
| PubChem CID | |
| IUPHAR/BPS | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.073.179 |
| 化学信息 | |
| 化学式 | C16H25NO2S |
| 摩尔质量 | 295.44 g·mol−1 |
| 3D模型（JSmol） | |
| 手性 | 外消旋体 |
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特他洛尔（英语：Tertatolol），商品名Artex、Artexal、Prenalex，是一种β受体阻滞剂，用于治疗高血压。它是由法国施维雅制药公司发现的，并在欧洲销售。[1]
特他洛尔还被证明可作为血清素5-HT1A和5-HT1B受体拮抗剂，类似于普萘洛尔和吲哚洛尔。[2][3][4]
参见
[编辑]参考资料
[编辑]- ^ Swiss Pharmaceutical Society. Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. 2000. ISBN 3-88763-075-0.
- ^ Langlois M, Brémont B, Rousselle D, Gaudy F. Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors. European Journal of Pharmacology. January 1993, 244 (1): 77–87. PMID 8093601. doi:10.1016/0922-4106(93)90061-d.
- ^ Jolas T, Haj-Dahmane S, Lanfumey L, Fattaccini CM, Kidd EJ, Adrien J, et al. (-)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain. Naunyn-Schmiedeberg's Archives of Pharmacology. May 1993, 347 (5): 453–463. PMID 7686633. S2CID 22129922. doi:10.1007/bf00166735.
- ^ van Wijngaarden I, Soudijn W, Tulp MT. 5-HT1A Receptors. Soudijn W, Olivier B, van Wijngaarden I (编). Serotonin Receptors and Their Ligands. Amsterdam: Elsevier. 1997. ISBN 0-444-82041-8.