孕烷醇酮
此條目介紹的是孕酮的3α,5β-还原产物。关于孕烷醇酮的其它立体异构体，请见「孕烷醇酮 (消歧义)」。| 孕烷醇酮 | |
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| IUPAC名 1-[(3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone | |
| 别名 | Eltanolone; 5β-Pregnan-3α-ol-20-one; 3α-Hydroxy-5β-pregnan-20-one; 3α,5β-Tetrahydroprogesterone; 3α,5β-THP; 3α-Hydroxy-5β-tetrahydroprogesterone |
| 识别 | |
| CAS号 | 128-20-1 |
| PubChem | 31402 |
| ChemSpider | 29132 |
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| InChI |
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| InChIKey | AURFZBICLPNKBZ-YZRLXODZBF |
| ChEBI | 1712 |
| 性质 | |
| 化学式 | C21H34O2 |
| 摩尔质量 | 318.49 g·mol−1 |
| 药理学 | |
| 给药途径 | Intravenous injection[1] |
| 药代动力学： | |
| 0.9–3.5 hours[1][2][3] | |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
孕烷醇酮（英語：Pregnanolone，也名为3α,5β-孕烷醇酮）也被称为乙他诺隆（英語：eltanolone）是一种内源性的抑制性神经甾体，在体内由孕酮合成而来[4]，和其异构体别孕烷醇酮有着类似的性质[4]。
参考文献
[编辑]- ^ 1.0 1.1 Carl P, Høgskilde S, Lang-Jensen T, et al. Pharmacokinetics and pharmacodynamics of eltanolone (pregnanolone), a new steroid intravenous anaesthetic, in humans. Acta Anaesthesiol Scand. October 1994, 38 (7): 734–41. PMID 7839787. doi:10.1111/j.1399-6576.1994.tb03987.x.
- ^ Gray HS, Holt BL, Whitaker DK, Eadsforth P. Preliminary study of a pregnanolone emulsion (Kabi 2213) for i.v. induction of general anaesthesia. Br J Anaesth. March 1992, 68 (3): 272–6. PMID 1547051. doi:10.1093/bja/68.3.272.
- ^ Carl P, Høgskilde S, Nielsen JW, Sørensen MB, Lindholm M, Karlen B, Bäckstrøm T. Pregnanolone emulsion. A preliminary pharmacokinetic and pharmacodynamic study of a new intravenous anaesthetic agent. Anaesthesia. March 1990, 45 (3): 189–97. PMID 2334030. doi:10.1111/j.1365-2044.1990.tb14683.x.
- ^ 4.0 4.1 Reddy DS. Pharmacology of endogenous neuroactive steroids. Crit Rev Neurobiol. 2003, 15 (3–4): 197–234. PMID 15248811. doi:10.1615/critrevneurobiol.v15.i34.20.